Thursday, February 28, 2013

H+K Strategies UK's Blog ? Blog Archive ? An Apple a Day

In the past week, there have been a number of interesting healthcare stories that have been making noise in the digital world.

As we?ve seen on this blog, the number of healthcare apps are ever increasing and now this growth has been truly cemented and recognised by none other than Apple. For a while, Apple has been creating lists of its favourite apps for specific demographics, including children, parents and film lovers. The new Healthcare Professional (HCP) list categorises apps that HCPs can use for reference, medical education, imaging, patient education, personal care and patient monitoring. Although iTunes have only made these available in the US, what?s interesting is that the list includes apps from pharmaceutical companies, including Novartis and Medtronic. Understanding and keeping track of how to get onto the list could be crucial for pharma companies to gain more visibility for their apps and help bring greater HCP engagement?to mainstream attention.

Another story that garnered significant attention was that of the world?s first live-tweeted C-section. The Memorial Hermann Hospital in Houston tweeted the whole C-section surgical procedure from beginning to end, with followers able to see the process in real time. Essentially an educational procedure, this garnered a large amount of traction, with an estimated 72,000 people watching the C-section live on Twitter and an additional 11,000 viewing it in another format. This is not the first time a surgical procedure has been live-tweeted, with the same hospital carrying out a live brain surgery and live heart surgery last year. The popularity of this is a clear sign of ?the educational value this type of digital format offers as well as perhaps whetting the (somewhat gory) appetite of many online.

As communicators, when creating campaigns we know how important it is to target the right audience with the right message. Previously, studies have shown women to be the influencers and decision makers in the household, and the results of recent survey have now shown that women are more likely than men to search for health information and advice online. According to a survey from the Pew Research Centre, 79% of female internet users vs 65% of male internet users went online to look for health information. These percentages overall are quite high, proving the potential reach an online campaign can have. This also demonstrates that when considering a digital campaign, it is important to think about whether it is right for your target audience, and the stats below, although US focused, provide a useful breakdown of which demographics are most likely to engage in the online space.

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Source: http://blogs.hillandknowlton.com/hank/?p=6776

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Family Fun Day | Levittown Sports & Recreation, Fairs & Festivals ...

Commerical Real Estate Tips From The Pros - Nasdaq Report News

Investing in commercial real estate has many rewards, but it also comes with devoting considerable time and effort. Perhaps you are confused about where to start. This article is for all you commercial property tycoons out there, and it is packed full of tips that will help to get you started in the commercial property market.

Don?t underestimate the value of networking with other investors or with private lenders when trying to purchase commercial real estate. Many commercial real estate is bought and sold without ever being on the market. Networking far and wide will keep you up-to-date on what?s going on in the industry and also make you privy to great deals.

Watch for motivated sellers. Sometimes you will find sellers who are willing and able to sell well below the market value. When you find the motivated seller, you?ll find your deal; nothing can happen before then.

When purchasing commercial real estate, always keep your goals in mind. Will you lease the property out or conduct business there yourself? You should sit down and make specific and straightforward goals for your commercial property, as it will save you time and effort.

One of the biggest differences between a residential loan and a commercial one is the size of the down payment you?re required to make. Try to locate the best lenders; then try asking for any quality investments. Both of these are a great way for you to increase your changes of qualifying for a commercial loan.

Unit Property

When investing in commercial real estate, go bigger. You may find that upkeep and operations for a twenty-unit property may actually be comparable to those required of a five-unit property. You must get commercial financing for any commercial venture, whether 5 units or 50 or more. The more units you finance, the less cost per unit!

Get a site checklist if you are viewing more than one property. Whilst you can take the first proposal responses, make sure that you don?t go any further without first informing the property owners of your plans. Consider allowing it to slip out that you are also looking at other properties. You might walk away with more money in your pocket.

Only work with companies that are sincerely interested in the success of their customers. Otherwise, it might cost you a lot of money in the future for something you could have easily avoided.

Real Estate

Be cautious of signing standard lease forms when leasing commercial real estate. Real estate companies often insert additional caveats in the fine print of long lease documents; take as much time as you need to read and understand what you?re signing. Only by going through the document with care can you prevent the potential pains and aches that you can get from standard commercial lease paperwork.

To prepare for any sizable investment in commercial real estate, investigate indicators of fiscal health around the property in question, such as average income levels for nearby residents, rates of employment and unemployment, and whether jobs in the area are rising or falling. Having a house located near a hospital, business sector, university or other school will greatly increase your home?s value, and provide you with a better chance for quickly selling it.

Focus on only one investment at the same time. You will get better results if you stick to a single type of investment rather than doing land leasing, apartments, and offices all at once. Each kind demands and is worthy of your complete and focused attention. Mastering one type of investment will set you up for success much faster then spreading yourself across many mediocre investments.

Clearly, owning and purchasing commercial property takes work, effort and research so that your experience is as favorable as possible. It?s also worth mentioning that it?s a never-ending process. Take the advice from this article to heart, and follow it and your dream of owning commercial property.

It?s great to know that you can do very well if you learn about Business News. Because you are now armed with this excellent advice, your life can be much easier. Use this knowledge to your advantage and you won?t have any problems in the future getting things done.

Related Posts:

Source: http://nasdaqreportnews.com/2013/02/27/commerical-real-estate-tips-from-the-pros/

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Union Budget 2013: Expect relief for salary earners, households ...

UPA-II?s last budget may offer some sops to salary earners and households as Finance Minister P Chidambaram will look to balance the compulsions of growth and fiscal prudence with election year politics.

The biggest challenge before Chidambaram, who will be presenting his eighth budget, would be to keep every constituent happy, arrest decelerating economic growth and bring down fiscal deficit to the committed level of 4.8 percent of GDP.

The Budget is also significant as it will be the last before the general elections due in April-May next year. There can only be an interim budget before the elections.

Some sops are likely

Some sops are likely

Among other things, Chidambaram will be under pressure to earmark funds for schemes and programmes to fulfil electoral promises, especially with regard to the Food Security Bill which seeks to provide subsidised foodgrain to poor as a matter of legal right.

The Economic Survey, which precedes the budget, is not in favour of the imposition of tax on super rich, stating that the government should focus on widening the tax base in preference to raising rates. The final call, however, will have to be taken by Chidambaram.

Salary earners may get some relief, with the Minister likely to raise the income tax exemption limit, which is currently at Rs 2 lakh per annum. The Parliamentary Standing Committee on Finance had suggested that the limit be raised to Rs 3 lakh and other slabs adjusted to provide relief to people reeling under the impact of high inflation.

Chidambaram is also expected to tweak schemes like the Rajiv Gandhi Equity Savings Scheme (RGESS) to encourage individuals to invest surplus funds in stock markets. The effort would be to do away with grey areas and make schemes more attractive to first time investors.

His main task however, would be to arrest declining growth, which is likely to fall to a 10-year low of 5 percent in 2012-13. The contracting industrial production will also require the Minister?s attention.

The Survey has indicated that growth in the next fiscal could be in the range of 6.1-6.7 percent.

The Finance Ministry may also announce steps to raise tax and non-tax revenue and cut expenditure to keep the fiscal deficit under check.

On the tax front, Chidambaram is likely to incorporate some of the provisions of the Direct Taxes Code (DTC) in the tax proposal, besides announcing a roadmap for implementation of the Goods and Services Tax (GST).

As regards disinvestment, the Minister is likely to raise the target to Rs 40,000 crore for 2013-14, from Rs 30,000 crore budgeted for this fiscal. However, the government may raise only Rs 27,000 crore in the current fiscal.

While attributing declining growth to global and domestic factors, the Survey underlines the need for policy actions to spur growth.

PTI

Source: http://www.firstpost.com/business/union-budget-2013-expect-relief-for-salary-earners-households-642708.html

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Wednesday, February 27, 2013

Researchers explore PKC role in lung disease

Tuesday, February 26, 2013
A JGP study examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases. The diagram shown summarizes the pathways regulating airway smooth muscle contraction. Credit: Dixon, R.E., and L.F. Santana. 2013. J. Gen. Physiol. appear in The Journal of General Physiology, provide new insight into the mechanisms involved in regulating luminal diameter of small airways and reveal PKC as a potential target for drug therapies.

The researchers used phase-contrast video microscopy, confocal microscopy, Western blot analysis, and pharmacological activators and inhibitors to investigate the role of PKC in airway SMC contraction in mouse lung slices. Their results suggest that activation of PKC in small airways promotes an influx of calcium into SMC and subsequent intracellular release of calcium ions to generate low frequency SMC twitching. PKC activation also induces a strong calcium ion sensitization of contraction, eliciting a stronger contractile response to stimuli that increase free intracellular calcium. Consequently, PKC activation downstream of various molecules, such as thrombin, that are present in the airways in conjunction with inflammatory lung diseases, could sensitize the airway SMCs to contractile stimuli and contribute to the airway hyper responsiveness that is characteristic of asthma and COPD.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 27 time(s).

Source: http://www.labspaces.net/127020/Researchers_explore_PKC_role_in_lung_disease_

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Contaminated diet contributes to exposure to endocrine-disrupting chemicals: Phthalates and BPA

Feb. 27, 2013 ? While water bottles may tout BPA-free labels and personal care products declare phthalates not among their ingredients, these assurances may not be enough.

According to a study published February 27 in the Nature Journal of Exposure Science and Environmental Epidemiology, we may be exposed to these chemicals in our diet, even if our diet is organic and we prepare, cook, and store foods in non-plastic containers. Children may be most vulnerable.

"Current information we give families may not be enough to reduce exposures," said Dr. Sheela Sathyanarayana, lead author on the study and an environmental health pediatrician in the UW School of Public Health and at Seattle Children's Research Institute. She is a physician at Harborview Medical Center's Pediatric Environmental Health Specialty Unit, and a UW assistant professor of pediatrics.

Phthalates and bisphenol A, better known as BPA, are synthetic endocrine-disrupting chemicals. Previous studies have linked prenatal exposure to phthalates to abnormalities in the male reproductive system. Associations have also been shown between fetal exposure to BPA and hyperactivity, anxiety, and depression in girls.

The researchers compared the chemical exposures of 10 families, half of whom were given written instructions on how to reduce phthalate and BPA exposures. They received handouts prepared by the national Pediatric Environmental Health Specialty Units, a network of experts on environmentally related health effects in children. The other families received a five-day catered diet of local, fresh, organic food that was not prepared, cooked or stored in plastic containers.

When the researchers tested the participants' urinary concentrations of metabolites for phthalates and BPA, they got surprising results. The researchers expected the levels of the metabolities to decrease in those adults and children eating the catered diet.

Instead, the opposite happened. The urinary concentration for phthalates were 100-fold higher than the those levels found in the majority of the general population. The comparison comes from a study conducted by the National Health and Nutrition Examination Survey. This is a program of studies managed by the Centers for Disease Control and Prevention and designed to assess the health and nutritional status of adults and children in the United States.

The concentrations were also much higher for children as compared to the adults. The researchers then tested the phthalate concentrations in the food ingredients used in the dietary intervention. Dairy products -- butter, cream, milk, and cheese -- had concentrations above 440 nanograms/gram. Ground cinnamon and cayenne pepper had concentrations above 700 ng/g, and ground coriander had concentrations of 21,400 ng/g.

"We were extremely surprised to see these results. We expected the concentrations to decrease significantly for the kids and parents in the catered diet group. Chemical contamination of foods can lead to concentrations higher than deemed safe by the US EPA," said Dr. Sheela Sathyanarayana.

Using the study results, the researchers estimated that the average child aged three to six years old was exposed to 183 milligrams per kilogram of their body weight per day. The U.S. Environmental Protection Agency's recommended limit is 20 mg/kg/day.

"It's difficult to control your exposure to these chemicals, even when you try," said Sathyanarayana. "We have very little control over what's in our food, including contaminants. Families can focus on buying fresh fruits and vegetables, foods that are not canned and are low in fat, but it may take new federal regulations to reduce exposures to these chemicals."

The other researchers in the study included Garry Alcedo (Seattle Children's Research Institute), Brian E. Saelens and Chuan Zhou (UW Department of Pediatrics, Seattle Children's Research Institute), Russell L. Dills and Jianbo Yu (UW Department of Environmental and Occupational Health Sciences) and Bruce Lanphear (BC Children's Hospital and Simon Fraser University).

Their paper is titled, "Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposure."

The study was supported through by the Center for Ecogenetics and Environmental Health in the Department of Environmental and Occupational Health Sciences in the UW School of Public Health. A grant from the National Institute of Environmental Health provides major support for the center.

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The above story is reprinted from materials provided by University of Washington. The original article was written by Elizabeth Sharpe.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sheela Sathyanarayana, Garry Alcedo, Brian E Saelens, Chuan Zhou, Russell L Dills, Jianbo Yu, Bruce Lanphear. Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures. Journal of Exposure Science and Environmental Epidemiology, 2013; DOI: 10.1038/jes.2013.9

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/nutrition/~3/UkiRRvtC_IE/130227121903.htm

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Lindsay Lohan Claims Cops Did Not Read Her Rights, Were Totally Mean

Source: http://www.thehollywoodgossip.com/2013/02/lindsay-lohan-claims-cops-did-not-read-her-rights-were-totally-m/

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To Build An Empire, Hold The Anchovies

Located north of Lima, Peru, the Caral-Supe settlement was the ancient home of the Norte Chico people, a civilization almost as old as the Egyptians.

Courtesy of Chris Kleihege

Located north of Lima, Peru, the Caral-Supe settlement was the ancient home of the Norte Chico people, a civilization almost as old as the Egyptians.

Courtesy of Chris Kleihege

Megalomaniacs, consider yourselves warned. Anchovies will not help you build your empire. To rule long and prosper, serve corn.

That's the word from archaeologists who say they've solved a mystery that has been puzzling their colleagues for the past 40 years: How did some of the earliest Peruvians manage to build a robust civilization without corn ? the crop that fueled other great civilizations of the Americas, like the Maya?

The Norte Chico people, who lived some 5,000 years ago, built a thriving civilization ? but from the archaeological evidence previously available, it looked like they did it solely on anchovies. And anyone who has ever nibbled an anchovy on a pizza knows there's not a lot of meat on those tiny bones.

Would that have given the Norte Chico enough oomph to build the monumental architecture they left behind, including dozens of large communities with huge earthen platforms and circular ceremonial plazas, some 40 meters across?

A view of one of the ceremonial plazas at the Caral-Supe archaeological site.

Ernesto Benavides/AFP/Getty Images

A view of one of the ceremonial plazas at the Caral-Supe archaeological site.

Ernesto Benavides/AFP/Getty Images

"Think about anchovy at every meal you ate," says Jonathan Haas, an archaeologist at the Field Museum in Chicago. "The problem with anchovies is if you are going to get calories out of them, you have to eat a lot of them, and it's not a balanced diet."

Agriculture is considered the engine of civilization, and in the Americas, that means corn.

Though very little evidence of corn consumption had been found in Peru dating back to the time of the Norte Chico, Haas and his colleagues figured these people just had to be eating corn. So they decided to look harder.

First, they searched Norte Chico archaeological sites north of Lima for proof that the ancient Peruvians had been growing corn. They found lots of old maize pollen.

Then, they went looking for pollen on the stone tools the residents of Norte Chico used to cook. They looked under the microscope, and "lo and behold, the large majority of the tools are being used to process maize," Haas tells The Salt.

Finally, they looked in the fossilized human poop found in the sites. They found anchovy bones ? and lots of corn starch. And that's not all: Turns out, sweet potatoes were the second most popular carbohydrate, and guava the most popular source of sugar. (You can learn a lot from fossilized feces.)

Haas says this "corn rules" thesis may be controversial, but he thinks his team's data are strong enough to hold up. The work was published in the Proceedings of the National Academy of Sciences.

"Rather than being a maritime-based society, it's an agriculturally based society," Haas says. "South America then falls in line with the rest of the civilizations of the world."

Update: Photographer Chris Kleihege, whose photo project is documenting excavations at Caral-Supe, sends this photo of a 5,000-year-old corncob found at a pyramid at the ancient Peruvian site.

Source: http://www.npr.org/blogs/thesalt/2013/02/25/172896292/to-build-an-empire-hold-the-anchovies?ft=1&f=1007

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Kerry, Russian counterpart Lavrov talk about Syria

BERLIN (AP) ? U.S. Secretary of State John Kerry and his Russian counterpart, Sergei Lavrov, met for the first time Tuesday, spending more than an hour discussing the civil war in Syria and other joint matters.

State Department spokeswoman Victoria Nuland said the two met for an hour and 45 minutes, spending more than half that time on Syria in what she called a "really serious and hardworking session."

Kerry and Lavrov discussed how they could implement the so-called Geneva Agreement, which is designed to get the Syrian government and rebels to plan a transitional government for the time after President Bashar Assad leaves office.

That discussion comes two days before nearly a dozen nations, excluding Russia, meet in Rome Thursday with the Syrian opposition to continue to try and find a way forward on resolving the conflict that has cost nearly 70,000 lives.

Lavrov told Russian newswires that his talks with Kerry were "quite constructive."

"I have a feeling that President Barack Obama's second administration, in the foreign policy field led by John Kerry, will try to play a more constructive role in all those areas," Lavrov said.

On Syria, Lavrov said the two reaffirmed their "intention to do all Russia and the U.S. can do.

"It's not that everything depends on us, but we shall do all we can to create conditions for the soonest start of a dialogue between the government and the opposition."

The Syrian foreign minister was in Moscow on Monday and expressed willingness to meet with opposition leaders.

The Syrian National Coalition is skeptical about outside help from the West and threatened to boycott the Rome meeting until a series of phone calls and meetings between Kerry and his ambassadors and Syrian opposition leaders repaired the schism. The council now says it will attend the meeting, but is hoping for more concrete offers of help, including military assistance, which the United States and others have been unwilling to supply.

Kerry told reporters in London on Monday that when he was chairman of the Senate Foreign Relations Committee, he asked the Obama administration to consider supplying arms to the Syrian rebels. But now he noted that he is an administration official and has to follow administration policy.

Despite urging from Pentagon leaders including Defense Secretary Leon Panetta, President Barack Obama has opposed lethal aid.

Earlier in Berlin, Kerry told young Germans of his adventures as a 12-year-old son of an American diplomat in divided postwar Berlin, and urged them to be true to their ideals and values as Europe struggles to emerge from economic doldrums and deal with the threat of terrorism.

Speaking at a town hall meeting, Kerry spoke a few sentences of passable German to the delight of a crowd in a packed Internet cafe before regaling the audience with tales of his boyhood in Berlin in 1954.

He recalled a clandestine bicycle ride into communist East Berlin. "I saw the difference between east and west. I saw the people wearing darker clothing. There were fewer cars. I didn't feel the energy or the movement."

When he returned home, Kerry said, his father "got very upset with me and said: 'You could have created an international incident. I could have lost my job.' So I lost my passport, and I was grounded and I never made another trip like that."

Today, Kerry said: "I never forgot and now it's vanished. Now, so many other countries have followed with this spirit of giving life to people's individual hopes and aspirations."

Kerry urged Germans to be tolerant of all points of view.

"People have sometimes wondered about why our Supreme Court allows one group or another to march in a parade even though it's the most provocative thing in the world and they carry signs that are an insult to one group or another," he said. "The reason is, that's freedom, freedom of speech. In America you have a right to be stupid. ... And we tolerate it. We somehow make it through that."

Kerry also took the opportunity to plug a New England clothing line after one audience member complimented him on his pink tie. A graduate of the noted St. Paul's School in New Hampshire and Yale University, Kerry extolled the sartorial virtues of Vineyard Vines, a Connecticut purveyor of ? in its own description ? "preppy" clothes that has a pink whale for a logo.

"I don't own any stock in the company," he said to laughter.

Source: http://news.yahoo.com/kerry-russian-counterpart-lavrov-talk-syria-174315846--politics.html

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Syria says it's ready for talks with armed rebels

MOSCOW (AP) ? Syria is ready to hold talks with the armed opposition trying to topple President Bashar Assad, the country's foreign minister said Monday, in the government's most advanced offer yet to try to resolve the 2-year-old civil war through negotiations.

Walid al-Moallem did not say whether rebel fighters would first have to lay down their arms before negotiations could begin, a key sticking point in the past. Still, the proposal marked the first time that a high-ranking Syrian official has stated publicly that the government would meet with opposition fighters.

"We're ready for a dialogue with anyone who's willing for it," al-Moallem said in Moscow ahead of talks with his Russian counterpart, "even with those who carry arms. We are confident that reforms will come about not with the help of bloodshed but through dialogue."

One rebel commander welcomed the idea of talks, but only on the condition that Assad and those who are responsible for the bloodshed are put on trial.

Syria's 23-month-old conflict, which has killed more than 70,000 people and destroyed many of the country's cities, has repeatedly confounded international efforts to bring the parties together to end the bloodshed. Russia, a close ally of Assad and his regime's chief international advocate, offered last Wednesday, in concert with the Arab League, to broker talks between the rebels and the government.

The proposal ? which the Kremlin would be unlikely to float publicly without first securing word from Damascus that it would indeed take part ? suggested the regime could be warming to the idea of a settlement as it struggles to hold territory and win back ground it has lost to the rebels.

Syria's rebels have scored several tactical victories in recent weeks, capturing the nation's largest hydroelectric dam and overtaking airbases in the northeast. In Damascus, they have advanced from their strongholds in the suburbs into neighborhoods in the northeast and southern rim of the capital, while peppering the center of the city with mortar rounds for days.

On Thursday, a huge bomb blast near the ruling Baath party headquarters in Damascus killed at least 53 people, according to state media.

While the momentum may be subtly shifting in the rebels' direction, the regime's grip on Damascus remains firm, and Assad's fall is far from imminent ? or certain.

Ahead of the meeting with al-Moallem, Russian Foreign Minister Sergey Lavrov repeated his call for Syria to negotiate with the opposition, saying that "the situation in Syria is at a crossroads now." He also warned that further fighting could lead to "the breakup of the Syrian state."

Past government offers for talks with the opposition have included a host of conditions, such as demanding that the rebels first lay down their arms. Those proposals have been swiftly rejected by both activists outside the country and rebels on the ground.

The prospect of negotiating with the armed opposition is made all the more difficult by the fractured status of those fighting to topple the regime. There are dozens of armed brigades and groups across the country and no unified command.

The head of one group, Free Syrian Army chief Gen. Salim Idriss, said he is "ready to take part in dialogue within specific frameworks," but then rattled off conditions that the regime has rejected in the past.

"There needs to be a clear decision on the resignation of the head of the criminal gang, Bashar Assad, and for those who participated in the killing of the Syrian people to be put on trial," Idriss told pan-Arab Al-Arabiya TV.

He said the government must agree to stop all kinds of violence and to hand over power, saying that "as rebels, this is our bottom line."

Both sides in the conflict in recent weeks have floated offers and counter-offers to hold talks to resolve the crisis.

In a speech in January, Assad offered to lead a national dialogue to end the bloodshed, but said he would not talk with the armed opposition and vowed to keep on fighting. The opposition rejected the proposal.

This month, the leader of the Syrian National Coalition, the umbrella group for opposition parties, said he would be open to discussions with the regime that could pave the way for Assad's departure, but that the government must first release tens of thousands of detainees. The government refused, and even members within the Coalition balked at the idea of talks.

Speaking to reporters Monday in Cairo, SNC chief Mouaz al-Khatib accused the regime of procrastinating and said it had derailed his dialogue offer by not responding to the Coalition's conditions.

"We are always open to initiatives that stop the killing and destruction but the regime rejected the simplest of humanitarian conditions. We have asked that the regime start by releasing women prisoners and there was no response," he said. "This regime must understand that the Syrian people do not want it anymore."

Countries in the region have watched the Syrian conflict with trepidation, fearful that the bloodshed could drag in neighboring states.

Turkey, which has taken in tens of thousands of Syrian refugees and has exchanged fire across the border with government troops, is among those most concerned about the fallout.

Speaking to the U.N. Human Rights Council in Geneva, Turkish Foreign Minister Ahmet Davutoglu accused Damascus of using "every instrument to turn the legitimate struggle of the Syrian people into a sectarian war which would engulf the entire region in flames."

"The longer this regime is allowed to wage its campaign of violence, the harder it will be to prevent such a dreadful eventuality," he added.

Meanwhile, the fighting inside Syria rages on.

The Syrian Observatory for Human Rights activist group reported heavy clashes Monday outside a police academy in Khan al-Asal just outside Aleppo.

Rebels backed by captured tanks launched a fresh offensive on the facility on Sunday. Observatory director Rami Abdul-Rahman said at least 13 rebels and five regime troops were killed in the fighting.

In another part of Aleppo, rebels downed a military helicopter near the Mennegh airport, where there have been fierce clashes for months.

A video posted online by activists shows a missile being fired, a trail of white smoke and then the aircraft going up in flames. Voices in the background shout "God is great" as a man raises both hands in the air in celebration.

The video appeared to be authentic and corresponds to other AP reporting.

___

Lucas reported from Beirut. Associated Press writers Zeina Karam in Beirut and Geir Moulson in Berlin contributed to this report.

Source: http://news.yahoo.com/syria-says-ready-talks-armed-rebels-150339987.html

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Getting the Best Company VoIP Phone System | Communications

By Steven P. Garrison

A pro and efficient communication system is what a growing business needs to get even more successful.

To be well placed to battle against cutthroat competition, many companies employ a business VoIP phone system to enhance the way they communicate with their workers and clients. This phone system is cost effective, and provides fantastic benefits that one can not get in a typical business telephone system. As well as providing more features than its analog counterpart, it costs less.

Once a caller dials a business VoIP phone system, it is instantly transmitted with a digital format through the internet. It's going to be converted to voice data on the other end once the called party receives it.

When selecting your business VoIP phone system, think about this factor:

Scalability. It's an necessary aspect since most of the time you do not need to buy the biggest VoIP system available for your business. You must select the one which has expandability so that you can add more features when you want them.

You will select between a premise-based service and a VoIP service. Should you choose the VoIP service, all that you need to do is to plug your business VoIP phone system to the Internet and you are set. There is no need to pay for pricey hardware and care for its upkeep. If you choose the premise-based service, you are required to purchase the PBX and the VoIP telephones which should cost you more. This isn't usually used for small firms.

When you have decided to make use of the hosted VoIP system, you must rigorously choose the best one for your particular wishes. Choose the business VoIP phone system host which is reliable and will provide service 24/7. Any communication interruption is a business loss.

If you frequently make international calls using your business VoIP phone system, make sure you know its non-local call policy so you may know the closely related costs. But even on cross-country calls, you can save as much as 75%. This further proves the point that a VoIP phone system saves you money and adds pro image to your business.



About the Author:


We sell, install and provide support for FortiVoice, including the FortiVoice 200D-T Phone Systems, FortiVoice FortiFone FON-860i Phones and FortiVoice FortiCare Accessories. We offer free shipping and have a 30 Day Return Policy on systems.

Source: http://onlinescommunication.blogspot.com/2013/02/getting-best-company-voip-phone-system.html

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Swan Tower - How to write a long fantasy series

02:39 pm - How to write a long fantasy series

It took three years and two months rather than the two years I initially planned, but I have, at very long last, finished the Wheel of Time re-read and analysis. And as I promised quite some time ago, we?ll end with what I?ve learned.

This post, unlike the others, is not WoT-specific. I?ll be referencing the series, because it?s the primary source of my thoughts on this topic, but the point here is to talk about the specific challenges of writing a long epic fantasy series -- here defining ?long? as ?more than a trilogy, and telling one ongoing story.? (So something like Mercedes Lackey?s Valdemar books wouldn?t count, since they?re a conglomeration of multiple trilogies.) My points probably also apply to non-fantasy series, but other genres are much less likely to attempt multi-volume epics on this scale, so I?m mostly speaking to my fellow fantasists.

I do not pretend this is in any way, shape, or form a recipe for commercial success with an epic fantasy series. After all, most of this is a checklist of errors I feel Jordan made, and you could paper the walls of Tor?s offices in fifty-dollar bills with the cash he made for them. Nor am I claiming artistic failure awaits if you fail to heed this advice; you might squeak through on luck, or just really good storytelling instinct. But I do feel that bearing these points in mind can help the would-be writer of an epic series avoid falling off some of the more common and perilous cliffs.

With all of that intro material out of the way, let?s get to it.


On the basis of my re-read, and comparing to other series that attempt similar tasks, I have come to believe there is a single, fundamental principle, underlying all the other points I?ll make throughout this post, which governs the author?s ability to keep the narrative from spinning wildly out of control, to the detriment of their story.

It?s simple:

PICK A STRUCTURE, AND STICK TO IT.

Most of us, when we set out to write a novel, have at least a vague sense of how long it?s going to be. We can be off in that estimate -- In Ashes Lie ran about thirty thousand words longer than I originally intended -- but generally speaking, you know that you?re aiming for 60K or 100K or 200K, and you use that to guide a thousand decisions you make along the way. Should you introduce new subplots, or is it time to start tying things up? Does your protagonist?s next action need some complications along the way, or would it be better to just handle it offscreen and move on to more important things? Can you bring in a new character for this strand, or should you find a way to take care of things with the characters you already have? These are questions of pacing, and we?ll come back to that a bunch of times along the way. But you can?t gauge your pace when you don?t know how long the race will be: at best, you?ll end up going through the whole thing with a steady, slogging, workhorse pace that (to switch metaphors) loses all sense of dynamics.

Pick a structure, and stick to it.

By ?a structure? I mostly mean ?a set number of books,? though I allow that there might be other ways to conceive of it. J.K. Rowling knew the Harry Potter series would be seven books, and each book would span one academic year at Hogwarts (plus or minus a little time before or after). The actual size of those books varied wildly, and you can certainly make the argument that she would have benefited from tighter editing as the word-count ballooned. But does anybody think that situation would have been improved by her saying, ?There?s an awful lot of stuff to deal with in book five; I think I should split it in two?? I doubt it. (The decision to split the final film was likely drive as much by financial aspirations as artistic, if not more so. And oy vey is that the case with the two Breaking Dawn movies. But by then the material was set; the end was in sight.)

I haven?t read Steven Erickson?s Malazan books, but I?m told he set out to write a ten-book series, and that?s what he delivered. And you know what? Based on what I?ve heard from readers, some of them thought it was great, some of them thought it was flawed, but none of them thought it was the trainwreck of apocalyptically bad pacing the Wheel of Time turned into. Whether or not you liked where the story was going, it was indubitably going somewhere, and at a reasonable clip.

A Song of Ice and Fire, by contrast, was supposed to be a trilogy. Then a quartet. Then a sextet. Then A Dance With Dragons got too long, so Martin split it and now the series is a septet. In a recent interview, he said it might run to eight books instead. Step by step, I can see him walking into the same swamp Jordan got lost in.

Tom Smith discusses this in his essai Zeno?s Mountains, wherein he cites David Eddings saying that a man who?s never walked a mile has no real sense of how far a mile is. Most of us learn how much Stuff goes into a novel by writing one; we learn how much Stuff goes into a trilogy by doing the same. How many of us ever write more than one seven- or nine- or ten-book series, though? Jordan never got a chance to learn from his first attempt and do better the second time. Martin likely won?t, either.

Smith says, ?I do not know of any general solution to this problem; perhaps no general solution is possible.? I say there is a solution, and its name is Discipline.

As answers go, it isn?t perfect; keeping your series confined within its intended boundaries may result in a less satisfying arc for various plots than you would get if you let them stretch out to their fullest. But letting them stretch may very well be detrimental to other aspects of the story. Keep one eye always on the larger picture, and know what must be accomplished by the end of the current book for you to remain on schedule.

Doing so may require some ruthless editing. And it?s entirely possible that such editing won?t be in your best commercial interests: it costs time and effort, laid against the odds that allowing the story to sprawl will translate into more money for you and your publisher alike. From the standpoint of craft, though, rather than the bottom line:

Pick a structure, and stick to it.

Continuing onward from there, I have learned several other salutary lessons, most (if not all) of them standing on that structural foundation.

1. Control your points of view.

A friend of mine, in discussion regarding an epic fantasy series she?d like to write, proposed that this should be the number-one item on my list. I put it at number two because I believe structure is one of the major yardsticks by which the decision to add a new pov character should be measured.

I could point to any number of cautionary examples from the Wheel of Time (goddamed Vilnar Barada comes to mind, or Alteima), but I think it?s best to look at the moment where I first noticed Jordan going wrong. That would be the pov scene for Jaichim Carridin in The Shadow Rising, the fourth book of the series -- the one where the branching nature of the story is at its strongest, right before passing from being a feature into being a nigh-fatal bug.

For those who aren?t familiar with the Wheel of Time, Carridin is a minor villain character who gets four pov scenes in the entire series. In this particular scene, we discover that he?s scheming with Liandrin (another minor villain; she gets four pov appearances, too) on behalf of one of the factions he serves, and with the King of Tarabon on behalf of a different faction. Which sounds good, except that the key word in that sentence is ?discover? rather than ?scheme? -- relatively little action takes place. Most of Carridin?s 3,194 words are spent on him thinking about stuff: the current political situation in the city, the current political situation outside the city, the way his evil overlords have been slaughtering his family one member at a time to motivate him, etc.

Some of the information that appears in this scene also reaches us via different channels in the story. Other parts aren?t terribly relevant, because they don?t come to anything in the long run. Jordan could easily have cut this scene, and we would have lost very little of substance; the few salient details could have been brought in elsewhere, by other means.

But let?s pretend for a moment that the information here is actually vital. Does that justify spending time in the head of this minor villain?

No. Because here?s the thing: switching to Carridin is lazy. It?s the easiest way to tell us what the bad guys are doing -- and I do mean ?tell,? given that most of the scene is Carridin thinking rather than acting. Had Jordan restricted himself to a smaller set of pov characters, he would have been forced to arrange things so that his protagonists found out what Carridin was doing. In other words, they would have had to protag more. And that would have been a better story.

Every time you go to add a new point of view character, ask yourself whether it?s necessary, and then ask yourself again. Do we need to get this information directly, or see these events happen first-hand? Can you arrange for your existing protagonists to be there, or to find out about it by other means? Are you sure?

Given what I said above about sticking to your structure, there may indeed be times where it?s more word-efficient to jump to a new pov, rather than constructing a path by which your existing viewpoints can pick up the necessary threads. But be careful, because taking the lazy way out appears to be a slippery slope for authors. This page lists no less than sixty characters who get only a single pov scene each during the entirety of the Wheel of Time. Nineteen more get two apiece. Eleven get three, seven get four, and then the numbers start ticking upward faster, until our six primary characters have between fifty-seven and two hundred -- just to give you an idea of scale.

If I am counting correctly, this series has ONE HUNDRED TWENTY-NINE POINT OF VIEW CHARACTERS.

That is absurd.

Martin is starting to have a similar problem, albeit on a smaller scale. He has thirty-one viewpoint characters so far, according to this page. Fifteen of those -- nearly half! -- have been introduced or received pov in the last two books, and most of them have only one or two chapters apiece per book, well below the usual average for this series. One character in A Feast for Crows died at the end of his sole chapter, whereupon pov transferred to one of the people he?d been traveling with. Why not give that person viewpoint to begin with? Why not spend the pages developing that character, instead of the one who won?t be with us for long?

John Scalzi once pointed out the inexorable consequence of multiple points of view on pacing, which authors of long epics would do well to bear in mind. If you have a 120K book and one pov character, that?s a hundred and twenty thousand words forwarding that character?s story. If you split it evenly between two characters, they get 60K apiece. Four characters, and now each of them has only 30K in which to move forward. Pretty soon, it feels like not very much is happening with any one of them.

Of course, you can mitigate this to some extent by having those characters interact, so that A?s story is progressing even while we?re in B?s head. But that brings us to our next point . . . .

2. Control your subplots.

Once you have multiple pov characters, it?s easy to let them wander off from one another and start doing different things. This isn?t inherently bad; if you want to write a long epic fantasy series, you?re going to need a high degree of complexity. But if you lose sight of your structure, you?re liable to also lose sight of how many subplots is too many, and which ones are taking too long to resolve.

There are two ways to fall off this particular cliff. One is that you know X is going on in Y part of the world, but you?re afraid it won?t seem reasonable if you spring it on your reader at the point where X begins to affect the rest of the plot. (Or you just think it?s too shiny not to show, or whatever.) So you decide you need to show X happening -- and probably add a point of view to facilitate that. The other path starts with the point of view: having given a character pov rights, you feel consciously or subconsciously obligated to justify that decision. On a small scale, this leads to pointless crap like Vilnar Barada thinking about the girl he wants to marry; on a large scale, it leads to things like the Shaido Plot From Hell, which I am convinced was Jordan creating makework so that Perrin would have something to do, and also justifying Faile as an ongoing pov character.

It may annoy readers (especially when you do it badly), but I?ve come around to the philosophy that you shouldn?t be afraid to give one or more of your characters a sabbatical from the story. The example of Jordan doing this right is Perrin?s absence from The Fires of Heaven: Perrin had just won a great victory and settled into some necessary but unexciting work of consolidation, so it was a dandy time to step away and focus on other characters. The story would not have been improved by inventing a subplot to fill that gap. The example of Jordan doing it wrong is Mat?s absence from The Path of Daggers: Mat had just been trapped under a collapsing wall during the invasion of a city. It turns out nothing interesting had been going on with him during his book-long absence . . . but given where the story had left off with him, readers expected a great deal more, and didn?t get it. If you?re going to step away, choose the point at which something has wrapped up, not begun.

Making up subplots to keep a character busy is a cascading problem. The proliferating points of view created and/or abetted new plot complexity, which meant the central ropes of the narrative got stretched out farther than they were meant to go. You can?t shelve your main character for three books, though, so Rand -- ostensibly the driving force of the whole shebang -- didn?t have a lot to do for a while other than run around micro-managing the politics of several nations, creating a lot of material that didn?t really add all that much to the story. It did add words, though, which meant Jordan had to find something for Perrin to do while Rand was occupied, so Faile got kidnapped by the Shaido, and then next thing you know, you?ve created a monstrosity of a plotline that 80% of your readers will hate with the fire of a thousand suns, and oh by the way now you need to keep all those secondary characters busy, too, the ones who started this problem in the first place. It?s the principle of the Lowest Common Multiple, played out in narrative form: if one character is cycling at 13 rpm and another is at 20, you have to keep rolling until you hit 260 to get them both wrapping up at the same time. And that way lies the ever-expanding tale.

If you stick to your structure, you at least have a metric by which to gauge whether a subplot is worth the time it will take to cover it. Of course, most of us can?t really eyeball an idea and say ?why yes, that?s fifteen thousand words? worth of subplot? -- would that we could! But this gets back to the ?ruthless editing? I mentioned before. If it starts stretching out too far, find a way to accomplish the necessary elements more efficiently. If you can?t do that, cut the subplot. Yes, it may be shiny, but is it worth throwing off the balance of everything else in the story?

3. Centralize.

This is closely-enough related to the previous point that I almost folded it in there, but I think it deserves to be pulled out and looked at on its own.

A long series is going to have a certain amount of sprawl, which is both necessary and desirable. But keep an eye on how long it?s been since your major characters interacted with one another. In the Wheel of Time, the fourth book was the first one where the main protagonists didn?t all come together for the finale; not coincidentally, it?s also the last one where the story?s sprawl felt truly effective. Something like eight or nine books passed without Rand and Perrin seeing one another, or Perrin and Mat. There was a point in the story where Rand, Mat, Perrin, Egwene, and Elayne were all in different places doing different things, and had been for some time; that?s five major plots rolling without reference to one another, in addition to the countless minor plots. We may also consider that Martin?s story and pacing have begun to fall apart as he lets his characters separate further and further: when?s the last time you had any two of Arya, Jon, Bran, Sansa, Catelyn, and Tyrion in the same place at the same time? (Not to mention Daenerys, off on the other side of the planet this entire time, or the host of other pov characters Martin has begun to introduce.)

Remember Scalzi?s point above: the more you fragment the perspective, the less forward movement each one gets per book. Remember my corollary: you can mitigate that by having the viewpoints overlap. Apart from the simple mathematics of pacing, this helps deal with the subplot issue, because you can keep important characters in the narrative by having A work with B on whatever it is B?s doing. (Or oppose it, or interfere with it, or whatever.) And it will assist in maintaining your structure, because if Aragorn?s got to be at the Black Gates when Frodo arrives at Mount Doom, then you?ve got to get that Pelennor thing done on schedule, which means not letting the Paths of the Dead episode overstay its welcome.

(Note that I am NOT holding up Tolkien as a model for how to construct the kind of narrative I?m talking about here. His approach was to ignore half his story for half a book, which isn?t a tactic that will serve any modern author very well. But Lord of the Rings is familiar enough to serve as a useful example.)

So yes. By all means let your characters wander off and do their own thing . . . but not for too long. Bring them back together periodically, and look for ways to get multiple stones to work together on killing that bird.

4. The further you go, the less you have to show your math.

This is less tied into the structural base than the rest of my points; it?s more a simple matter of word bloat.

Early on in your story, it?s useful to show how your characters pull off their small accomplishments. It demonstrates their competence to us, if it?s something they?re supposed to be good at, or conversely shows them developing new skills, if they?ve been thrust into situations outside their usual depth. Or it establishes the realism of the world, or gives the reader information about a topic they may not know very well. All of that is perfectly fine.

But when you?re ten books into your series, you really don?t need to show the camp logistics of the army your hero has been in command of for the last four books. You don?t need to walk through every step of how the heroine, having attained her throne, arranges a meeting with some fellow sovereigns. You?ve already established that these are tasks well within their skill-set. We will not bat an eyelash if you go straight to the meeting, or have the army keep trucking along in good order. If you introduce some element that makes those tasks hard again, then by all means show how the new challenge is overcome -- but even then, you?re allowed to only focus on the challenging part, and let the routine stuff go.

Because in theory, the further you go into your series, the more exciting the story should be. Tensions mount! We?re building toward the climax! Now is not the time to stop and do the simple math all over again. Think of it like a geometry proof: once you?ve proved the basic theorems, you?re allowed to just cite them and move on, rather than having to go through every step every time.

One of the corollaries to this is more debatable. Re-reading the Wheel of Time, I was struck by how many times the story explains Min?s visions; it felt unnecessarily repetitive to me. Arguably, however, that sort of repetition is necessary, because some readers may not have read the previous book in a long time, and may have forgotten who Min is and what she can do. (Or they may have picked up the third book without having read the first two, though I tend to be of the opinion that people who do that deserve what they get. I note that many series, including both the Wheel of Time and Harry Potter, eventually give up on holding people?s hands -- it just takes a while.) This is more a matter of exposition than showing the narrative math, and I?ll allow that some amount of reinventing the wheel may be required. But keep an eye on it anyway, and try to keep it to a minimum.

There are many other things I could say about the flaws in the Wheel of Time, or in other long series. But these are the main points, the ones I think are universally applicable, rather than specific to a particular narrative -- along with, of course, the basic lessons of good writing, like not using twenty words where five will do. A story?s quality depends heavily on its shape, on the timing of various twists and revelations, the pacing of its arcs and the rate at which the characters grow; and good shape rarely happens by accident, especially on a large scale. Ergo, I firmly believe that you need some fixed points by which to navigate during your journey. Know how many books you?re going to write, hammer in a couple of pegs to say that certain events will happen at certain points, and then hold to your course. If you stray from the path, you may never find your way out of the woods.

Rumor has it, of course, that Jordan was asked to stretch the series out, because it was making so much money. I have no idea if that?s true. But as I said at the start, my concern here is not the commercial success of a series; I?m addressing the story itself.

I?m speaking, mind you, as someone who has yet to write a series longer than four books (and those structured almost entirely as stand-alones). This is all based on my observations of other people?s efforts, not my own experience. But as I said to Tom Smith in the comments to ?Zeno?s Mountains,? there?s not enough time in life to screw it up yourself for a dozen books, and then to do better afterward. If you want to write a long series and not have it collapse in the middle like a badly-made souffle, you have to learn from other people?s mistakes.

This entry was also posted at http://swan-tower.dreamwidth.org/577881.html. Comment here or there.

Source: http://swan-tower.livejournal.com/580795.html

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Tuesday, February 26, 2013

Viewing black bodies through photography | The Statesman

From the first caricatures of controversial character Sarah Baartman to posing in photos to female empowerment and exploiting stereotypes, Deborah Willis, the chair of photography and imaging at New York University?s Tisch School for the Arts, said the practice of taking pictures of the black body has changed.

Willis gave a presentation about taking photographs of the black body and how those images resonate with viewers on Thursday at the Charles B. Wang Center. During her speech, she went through pictures from the early 19th century to the present- day.

?What made you afraid of black people?? Willis said about the time that whites would use the black body for entertainment. ?What made you afraid of this??

In the late eighteenth century and early nineteenth century, people looked at black bodies as a humorous activity. Sarah Baartman, who was called the ?Hottentot Venus,? was put on display because of her enlarged buttocks and genitals.

When she died, her genitals were preserved and put on display in a French museum. Even after her death, her body was used for ridicule and one can still see this in pop culture and art.

Other photos showed women with their dresses pushed down and their breasts highlighted.

?Keep in mind what we know about images and what we know about people in terms of those images,? Willis said.

Frederick Douglass, a prominent abolitionist, who was one of the most photographed men of the 1800s, posed looking at the camera and looking off into the distance. According to Willis, Douglass knew that he was posing for his biography when he looked away in certain images.

Sojourner Truth, an abolitionist and women?s rights activist, posed for some photographs without her fancy drape to show her femininity. ?A photo of a Civil War major depicted him with a handkerchief that was meant to tell his story.

However, these posed photos also showed more humanized versions of the black body. One photo depicted a woman looking over her shoulder at the welts on her back from having been beaten.

?We see families of two young brothers and sisters,? Willis said. ?We are reminded that they are human.?

More recently, shooting photos of the black body has become more of a fabulist activity.

One photo shows a building that is shaped like a woman. The woman has an hourglass figure and the entrance is in her skirt. Willis called the skirt sexualized because to enter the building, one has to enter her skirt.

Willis showed Renee Cox?s image of one woman in a blue gown and another in a superhero costume, calling the vigilante ?Wonder Woman?s half-sister.?

?They are superwomen by taking care of their families,? Willis said.

Another photo that was meant to show how black men perceive black men showed a muscular gentleman in feminine garb. The photo was meant to emasculate men and empower women.

Advertising companies looking to expand their black consumer populations have been exploiting black stereotypes.

One automobile ad was a close-up photo of someone?s teeth. There was a gold car on one tooth, going off the stereotype that ?black people like to put gold on their teeth.? Another advertisement depicted a plain wooden table with a white plate. On the plate, there was a piece of watermelon and a scooper. The ad was for the scooper, but the advertisement stereotypically figured that black people like watermelon and would respond more positively to the campaign.

Willis ended the lecture by showing one of her own photo projects. ?The photo had boxes of pregnant women?s stomachs and pieces of motherly advice such as choosing the right person to marry.

Source: http://www.sbstatesman.com/2013/02/25/viewing-black-bodies-through-photography/

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BlackBerry launches first BB10 device in India at $800

MUMBAI (Reuters) - BlackBerry launched its first smartphone from its BlackBerry 10 line in India on Monday, pricing the phone at 43,490 rupees ($800).

The touch-screen BlackBerry Z10 phone, which goes on sale in India from Tuesday, will compete with Apple Inc's iPhones and Samsung Electronics Co Ltd's high-end Galaxy series phones.

The Z10 has already gone on sale in the United Kingdom and Canada, and is expected to hit the United States in mid-March.

(Reporting by Aradhana Aravindan; Editing by Devidutta Tripathy)

Source: http://news.yahoo.com/blackberry-launches-first-bb10-device-india-800-075200336--finance.html

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Taking the gamble out of DNA sequencing: How much can be learned in a large-scale experiment

Feb. 24, 2013 ? Two USC scientists have developed an algorithm that could help make DNA sequencing affordable enough for clinics -- and could be useful to researchers of all stripes.

Andrew Smith, a computational biologist at the USC Dornsife College of Letters, Arts and Sciences, developed the algorithm along with USC graduate student Timothy Daley to help predict the value of sequencing more DNA, to be published in Nature Methods on February 24.

Extracting information from the DNA means deciding how much to sequence: sequencing too little and you may not get the answers you are looking for, but sequence too much and you will waste both time and money. That expensive gamble is a big part of what keeps DNA sequencing out of the hands of clinicians. But not for long, according to Smith.

"It seems likely that some clinical applications of DNA sequencing will become routine in the next five to 10 years," Smith said. "For example, diagnostic sequencing to understand the properties of a tumor will be much more effective if the right mathematical methods are in place."

The beauty of Smith and Daley's algorithm, which predicts the size and composition of an unseen population based on a small sample, lies in its broad applicability.

"This is one of those great instances where a specific challenge in our research led us to uncover a powerful algorithm that has surprisingly broad applications," Smith said.

Think of it: how often do scientists need to predict what they haven't seen based on what they have? Public health officials could use the algorithm to estimate the population of HIV positive individuals; astronomers could use it to determine how many exoplanets exist in our galaxy based on the ones they have already discovered; and biologists could use it to estimate the diversity of antibodies in an individual.

The mathematical underpinnings of the algorithm rely on a model of sampling from ecology known as capture-recapture. In this model, individuals are captured and tagged so that a recapture of the same individual will be known -- and the number of times each individual was captured can be used to make inferences about the population as a whole.

In this way scientists can estimate, for example, the number of gorillas remaining in the wild. In DNA sequencing, the individuals are the various different genomic molecules in a sample. However, the mathematical models used for counting gorillas don't work on the scale of DNA sequencing.

"The basic model has been known for decades, but the way it has been used makes it highly unstable in most applications. We took a different approach that depends on lots of computing power and seems to work best in large-scale applications like modern DNA sequencing," Daley said.

Scientists faced a similar problem in the early days of the human genome sequencing project. A mathematical solution was provided by Michael Waterman of USC, in 1988, which found widespread use. Recent advances in sequencing technology, however, require thinking differently about the mathematical properties of DNA sequencing data.

"Huge data sets required a novel approach. I'm very please it was developed here at USC," said Waterman.

This research was funded by grants from the National Institutes of Health National Human Genome Research Institute (R01 HG005238 and P50 HG002790).

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The above story is reprinted from materials provided by University of Southern California, via EurekAlert!, a service of AAAS.

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Journal Reference:

  1. Timothy Daley, Andrew D Smith. Predicting the molecular complexity of sequencing libraries. Nature Methods, 2013; DOI: 10.1038/nmeth.2375

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/3-uOSnhnewE/130224142825.htm

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Firearms-makers to politicians on gun rights: You balk, we walk

Firearms companies ranging from gun shops to machinists are joining forces to oppose new gun control laws. Some are threatening to move away from states that crack down on guns, others are refusing to sell gear to police that can't be sold to citizens.

By Patrik Jonsson,?Staff writer / February 23, 2013

Germantown Police Officer Jeffrey Gonzalez loads a revolver for students to practice unloading it during the Concealed and Carry class at the Germantown Police Department in Germantown, Wis. Saturday.

John Ehlke/West Bend Daily News/AP

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A growing number of firearm firms in the US are vowing to reverse-boycott local and state governments that enact any new infringements on the Second Amendment.

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Vowing to close what they're calling "the police loophole," at least 50 US companies, ranging from gun machinists to gun shops, are now saying publicly they'll refuse to sell weapons and gear to police in places where governments have banned the use of the same gear by civilians.

Quality Arms, located in Rigby, Idaho, writes on its website that it "will not supply any firearm or product manufactured by us or any other company, nor will we warranty, repair, alter or modify a firearm owned by any state, county or municipality that infringes on the right of its citizens to bear arms under the 2nd Amendment."

How much do you know about the Second Amendment? A quiz.

The move comes as Congress and some state houses are considering new gun controls in the wake of the Dec. 14 massacre at Sandy Hook Elementary School in Newtown, Conn. The most direct target of the "police loophole" movement seems to be New York State, which put into law a raft of new gun control regulations, including limiting the size of magazines, last month.

"Based on the recent legislation in New York, we are prohibited from selling rifles and receivers to residents of New York [so] we have chosen to extend that prohibition to all governmental agencies associated with or located within New York," York Arms of Buxton, Maine, writes on its website.

So far, none of the major gun manufacturers have joined the list, and it's an open question whether the smaller companies are bluffing or would even have occasion to sell directly to governments in New York State, for example.

"Unless S&W, Springfield Armory, Ruger, Remington, etc. get on board, these boycotts are practically useless," writes an anonymous poster on the Sipsey Street Irregulars blog.

Meanwhile, the push for more gun control continues across the country, led by President Obama.

On Friday, Obama's political advocacy group, Organizing for Action, held over 100 events across the country, including letter-writing parties, rallies with police chiefs and mayors, and candlelight vigils, to push for Obama's federal gun control plan, which includes beefing up background checks and banning assault weapons and high-capacity magazines.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/gIoTCgvdjOA/Firearms-makers-to-politicians-on-gun-rights-You-balk-we-walk

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Business Ethics Keynote Speaker Chuck Gallagher Sirius Radio ...

Chuck Gallagher ? chuckgallagher.com ? is interviewed here by Lori Allen on FamilyNet TV and Sirius Satellite Radio about Business Ethics in today?s world. Chuck is an international business ethics keynote speaker ? speaking to organizations like the FBI, Medtronic, US Navy, Barclays, Institute of Management Accountants, and many more organizations. Gallagher shares his insight into the Bernie Madoff scandal and the inner workings of a Ponzi scheme. Currently COO of a National Company and former Sr. VP of Sales and Marketing for a Public Company, Chuck may have found a sales niche early on in life selling potholders door to door, or convincing folks to fund a record album of his musical performance at age 16 (and yes those were the days when an album was made of vinyl), but it was the school of hard knocks that provided a fertile training ground for Chuck?s lessons in Success. Described as Creative, Insightful, Captivating, and a person that ?Connects the Dots? between behavior, choices and success, Chuck Gallagher gives his clients what they need to turn concepts into actions and actions into results. Ethics in the workplace is a serious matter, but talking about it doesn?t have to be ?business as usual.? Chuck Gallagher learned a lesson about choices and consequences the hard way?but now he shares his experience so that others don?t have to. In his compelling presentations, Chuck starts by setting the scene with his own story? and ends by setting the stage for your ?
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Source: http://makemoneyhomebusinesscenter.com/business-ethics-keynote-speaker-chuck-gallagher-sirius-radio-lorri-allen-interview/

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New blood test finds elusive fetal gene problem

A NEW non-invasive blood test for pregnant women could make it easier to catch abnormalities before their child is born.

Human cells should have two copies of each chromosome but sometimes the division is uneven. Existing tests count the fragments of placental DNA in the mother's blood. If the fragments from one chromosome are unusually abundant, it might be because the fetus has an extra copy of that chromosome. But triploidy, where there are three copies of every chromosome, is missed, since the proportion of fragments from each chromosome is the same.

California-based company Natera uses an algorithm to calculate the most likely genotype for the fetus. To do this it looks at single letter variations called SNPs in the parents and compares this to a database of the most common SNPs patterns in the population. This genotype is then compared with placental DNA.

This approach can catch triploidy since the whole fetal genotype is the reference rather than a single chromosome. The method was presented last week at the Society for Maternal-Fetal Medicine in San Francisco.

This article appeared in print under the headline "No hiding place for fetal gene errors"

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